Is Advair, the Ultra-Popular Asthma Drug, Really Safe? - Daily Beast

by Jeff Gerth, ProPublica

Advair is one of the biggest blockbusters in pharmaceutical history.

The asthma drug has generated more than $80 billion in global revenues for its maker, GlaxoSmithKline, since its U.S. approval in 2000. With its distinctive purple inhaler, Advair has helped legions of asthma sufferers achieve control of their symptoms.

But recent federal research suggests that a significant percentage of asthma patients begin using Advair inappropriately, taking on what the drug’s label describes as an increased “risk of asthma-related death” from one of its two ingredients.

Concerns about that ingredient—salmeterol—emerged in a 1993 study, and more troubling results became known in early 2003. But it took the Food and Drug Administration seven more years to require Glaxo and makers of drugs similar to Advair to launch studies big enough to assess the risks.

Results aren’t due until 2017. Meantime, millions of patients on the drugs—a class long dominated by Advair—remain exposed.

Portions of Advair’s story have been told before , but a ProPublica examination, based on previously undisclosed or overlooked documents, shows that the traditional guardians of U.S. drug safety—manufacturers, regulators, doctors and the courts—have repeatedly failed to stop misuse of Advair or unlock its secrets.

Before Advair’s approval, a Glaxo scientist told the FDA that it wasn’t appropriate for patients with mild asthma. The agency agreed, a Glaxo document states, but it took five years to make that clear on the drug’s label.

When a handful of state Medicaid agencies moved to limit access to Advair, based on concerns about misuse, Glaxo lobbied aggressively to stop what was viewed internally as an “infestation” of such policies.

And Glaxo has faced scores of lawsuits and claims brought by people whose relatives have died while taking Advair, quietly settling some when pushed to the brink of...

Source: www.thedailybeast.com


Latest News

  • The Riggs Report: Black plate nostalgia

    06/25/15 ,via KCRA Sacramento

    The call, in fact, was from a woman in Bundaberg, Australia, whose husband had purchased a 1966 Ford Mustang from me a few months earlier. The Mustang was He's a car guy, as you might expect from someone raised in the car culture of the San

  • Is Advair, the Ultra-Popular Asthma Drug, Really Safe?

    05/19/15 ,via Daily Beast

    Within the latter group was Dr. Fernando Martinez, a prolific asthma researcher who runs a top respiratory center at the University of Arizona. Martinez .. Editor's note: The Sandler Foundation, the largest donor to ProPublica, also contributes to

  • Starbird-Devlin steps it up a notch

    01/24/15 ,via Kansas.com

    The workmanship and creativity on display were top-notch, with Al Seese's beautiful blue '33 Ford Sedan Delivery taking top honors. The car, based in Lee's Summit, Mo., is a former Ridler Great 8 machine. Rounding out the top three in the Magnificent 7

  • Henry Gevorgyan charged with murder after Mustang killed two in Los Angeles

    03/03/15 ,via Daily Mail

    The man accused of driving a souped-up Mustang that killed two men during an illegal street race in California was charged with murder - but an Instagram video may prove he wasn't at the wheel. Henry Gevorgyan was charged with two counts of murder

  • A New Undersheriff in Town

    01/08/15 ,via Pasadena Weekly

    He also opposed a 2004 proposed ordinance that sought to prevent gang members from riding bicycles, owning pagers, or wearing certain clothing. After former City Manager Cynthia Kurtz left Pasadena City Hall in 2007, Melekian was named interim city 


Books

  • Consumer Reports

    Saint Martin's Griffin. 2004. ISBN: 0890439877,9780890439876. 500 pages.
  • Reading real Russian

    1998. 274 pages.

    This proficiency-based reader introduces beginning- and intermediate-level readers to a strategy-based approach for dealing with a wide selection of authentic Russian texts through a variety of activities based on top-down and bottom-up processing strategies. Groups readings into 12 thematic units spanning a broad range of topics and interests. Covers several thematic categories, including — work and business; housing and real estate; shopping and economy; food and nutrition; computers and...


Directory

2004 Ford Mustang Parts In San Fernando Pampanga

Similar: new ford mustang victoria , ford custom. Image by cars.mitula.us ... 2004 Ford Mustang Parts In San Fernando Ca; 2004 Ford Mustang Parts In San Fernando ...

Ford Parts | San Fernando Valley - Sunrise Ford of North ...

Get Parts at Sunrise Ford of North Hollywood in North Hollywood, CA, serving San Fernando Valley. ... Ford Fusion; Ford Fusion Energi; Ford Mustang; Ford Taurus;

About Mustang Service Center:

About Mustang Service Center... Mustang Service Center is in its 20th year of service in the North Hollywood community of the San Fernando Valley ... quality in parts.

Ford dealership in North Hills | Serving the Ford sales ...

... C-Max Hybrid, Taurus, Ford Mustang . SUVs include, Ford Edge ... Parts, Repair. Our San Fernando Valley Ford Service Department is ... Park, La Canada ...

Galpin Ford Parts & Accessories - Ford Parts Los Angeles ...

... San Fernando Valley. Buy Ford Parts at our North Hills Ford ... Ford Mustang; Ford ... Our San Fernando Valley Galpin Ford Service Department is equipped ...